Denise M. Reagan was born and raised in Jacksonville until she moved to Gainesville to earn a bachelor's degree from the University of Florida's College of Journalism and Communications. She spent spent the next twenty-five years working at newspapers and websites in Fort Wayne, Indiana; Detroit, Michigan; Minneapolis, Minnesota; Savannah, Georgia; and Fort Lauderdale, Florida. After the birth of her daughter, she returned to Jacksonville to be an assistant managing editor at The Florida Times-Union, where she oversaw design, copy editing, graphics, photography, and video. While there, she worked on the reorganization and redesign of its print and digital products. She then became editor of Folio Weekly, where she overhauled the alternative publication's website and dramatically increased its social media footprint. She also won an award for her editorials from the Association of Alternative Newsmedia. In December 2013, Reagan became the director of communications at MOCA Jacksonville, where she oversees all the Museum's print and digital communications, from collateral and wall text to media relations and social media posts. Reagan is an experienced public speaker who has given presentations for professional organizations in Mexico, Canada, China, and throughout the United States. A longtime member of the Society for News Design, she served on the board, judged international competitions, wrote for publications, organized and hosted countless events, and won dozens of design awards. She has worked as a consultant on several publication redesigns around the country. As an adjunct professor at the University of Florida, Reagan has taught news design at the College of Journalism and Communications. She is a board member of the nonprofit PB&J and coordinates the series of Pecha Kucha talks in Jacksonville.
She is now senior manager of public relations at Brunet-García Advertising, the company MOCA Jacksonville has contracted with for its communications work.